B
Will these harm your system in any way?
I
Like when you patch a Japanese game to English? In that case no, it won't harm your system.
D
Patched ROMs typically don't hurt your system. you have to worry more about the data getting corrupted. Like a save file can get corrupted if you're not careful. But the only games I have patched are Soma Bringer and Ragnarok Online. And they both work just fine.