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just a few hours ago, acekard 2i team released the update file to make the ak2i work on DSi V1.43 and 3DS V2.1.-3. It also has been confrimed by some players, so you can update your card now. As usual, you need to bring a DS or DSi to update your card! Details below
AK2i update for 3DS2.1 and DSi1.4.3
This update support 3DS2.1 and DSi1.4.3. Please refer to readme file in the package.
Please choose update file according to your console. If you're using DSi or DSXL please use ak2ifw_update_3ds21_DSi143.nds to update. I f you're using DSL or DSPhat please useak2ifw_update_3ds21_DSi143_onDSL.nds to update.
Just follow the instructions after you run the update file.
Download the ak2i V1.43 firmware from here :
ak2i DSi V1.43 update patchand also the
Akaio V1.87 firmware in case you need!
And also more acekard 2i info here
Ak2i

Here is the youtube video about it
http://www.youtube.com/watch?v=T9XCnoahbX0